Recently, we demonstrated that GNF-2, an allosteric c-Abl inhibitor, rheostatically enhanced IRE1α activity and induced apoptosis through c-Abl conformational changes in pancreatic β cells. In multiple myeloma, adaptive IRE1α signaling is predominantly activated and regulates cell fate along with PERK. As the two grow close, Kei must deal with a completely new experience-jealousy.Endoplasmic reticulum stress activates inositol-requiring enzyme 1α (IRE1α) and protein kinase, R-like endoplasmic reticulum kinase (PERK), the two principal regulators of the unfolded protein response (UPR). But instead of resenting him, Hikari recognizes Iori as a kindred spirit as they both aim for the number one spot. The world of the SA class is turned upside down when Iori Tokiwa, a new student, transfers in and takes second place after Kei in the rankings, knocking Hikari down to third. Now, at 15, Hikari joins Special A, a group of the top seven students at a private academy, for the opportunity to trounce the guy who made her suffer her first defeat. He always comes out on top no matter what he does, and Hikari is determined to do whatever it takes to beat this guy.somehow!At age 6 Hikari lost to Kei in an impromptu wrestling match. Her whole life, Hikari Hanazono has been consumed with the desire to win against her school rival, Kei Takishima-at anything.
The world of the SA class is turned upside.
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